Last Updated: January 2, 2024 Introduction to the β-Thalassemias The human β-globin gene cluster is located on chromosome 11 (specifically 11p15.4) and includes the genes that encode the epsilon globin (ε: embryonic), the gamma A and gamma G globins (Aγ; Gγ: fetal),...
Last Updated: November 22, 2023 Introduction to the α-Thalassemias The thalassemias are the result of quantitative abnormalities in hemoglobin synthesis. With the α-thalassemias the level of α-globin production can range from none to very nearly normal...
Last Updated: January 18, 2024 Introduction to Sickle Cell Anemia Sickle cell anemia, also called sickle cell disease (SCD), is an autosomal recessive disorder affecting the function of hemoglobin. In order for full disease symptoms to manifest in an individual they...